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Merck Enters Exclusive Alliance with Hansoh Pharma for Oral GLP-1 Candidate

Hansoh Pharma will receive $112 million upfront and is eligible to receive up to $1.9 billion in milestone payments.

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By: Kristin Brooks

Managing Editor, Contract Pharma

Merck and Hansoh Pharma, a Chinese biopharmaceutical company, have entered into an exclusive global license agreement for HS-10535, an investigational preclinical oral small molecule GLP-1 receptor agonist.
 
Under the agreement, Merck gains an exclusive global license to develop, manufacture and commercialize HS-10535. Hansoh Pharma will receive an $112 million upfront and is eligible to receive up to $1.9 billion in milestone payments associated with the development, regulatory approval and commercialization of the candidate, as well as royalties on sales. Hansoh Pharma may co-promote or solely commercialize HS-10535 in China subject to certain conditions. 
 
“We continue to leverage science-driven business development to augment and complement our robust pipeline,” said Dr. Dean Y. Li, president, Merck Research Laboratories. “Through this agreement, we aim to build on our experience targeting incretin biology to evaluate HS-10535 and its potential to provide additional cardiometabolic benefits beyond weight reduction.”
 
“We are pleased to announce the in-license of our oral GLP-1 by Merck, a company with established leadership in cardiometabolic diseases,” said Ms. Eliza Sun, Executive Director of the Board, Hansoh Pharma. “Hansoh Pharma is becoming an emerging leader in metabolic diseases, and we see Merck’s expertise and capabilities as key to accelerating the development of this promising asset for patients worldwide.”

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